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GAP-134 hydrochloride

CAS No. 943133-81-1

GAP-134 hydrochloride( Danegaptide Hydrochloride | ZP1609 Hydrochloride | GAP134 Hydrochloride | GAP 134 Hydrochloride )

Catalog No. M16752 CAS No. 943133-81-1

A potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GAP-134 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle.
  • Description
    A potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle; has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.Heart Arrhythmia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Danegaptide Hydrochloride | ZP1609 Hydrochloride | GAP134 Hydrochloride | GAP 134 Hydrochloride
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Gap Junction Protein
  • Recptor
    Gap Junction Protein
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    943133-81-1
  • Formula Weight
    327.7634
  • Molecular Formula
    C14H18ClN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1C(CN(C1C(=O)O)C(=O)CN)NC(=O)C2=CC=CC=C2.Cl
  • Chemical Name
    L-Proline, glycyl-4-(benzoylamino)-, hydrochloride (1:1), (4R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Butera JA, et al. J Med Chem. 2009 Feb 26;52(4):908-11. 2. Rossman EI, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. 3. Hennan JK, et al. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14.
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